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Recent Publications of Members of the Boston Ithaca Islet Club


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2010
Gray JP, Heart E.  2010.  Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion. Toxicol Mech Methods. 20:167-174. Abstract
2009
Guay C, Goudreault D, Schanzer W, Flenker U, Ayotte C.  2009.  Excretion of norsteroids' phase II metabolites of different origin in human. Steroids. 74(3):350-8. Abstract
Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.  2009.  Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 58(3):682-92. Abstract
Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME.  2009.  ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol. Abstract
Wikstrom JD, Twig G, Shirihai OS.  2009.  What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. Abstract
Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.  2009.  Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem. 284(25):16848-59. Abstract
Harbilas D, Martineau LC, Harris CS, Adeyiwola-Spoor DC, Saleem A, Lambert J, Caves D, Johns T, Prentki M, Cuerrier A, Arnason JT, Bennett SA, Haddad PS.  2009.  Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II. Can J Physiol Pharmacol. 87(6):479-92. Abstract
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.  2009.  Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 29(11):3219-28. Abstract
Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.  2009.  Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass. Diabetologia. 52(6):1122-32. Abstract
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ.  2009.  Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 296(6):E1354-62. Abstract
Bendayan M, Londono I, Kemp B, Hardie GD, Ruderman N, Prentki M.  2009.  Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immuno-electron Microscopy. J Histochem Cytochem. Abstract
Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.  2009.  The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets. Obesity (Silver Spring). Abstract
Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS.  2009.  Mitochondrial Networking Protects Beta Cells from Nutrient Induced Apoptosis. Diabetes. Abstract
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.  2009.  Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 150(7):3040-8. Abstract
Kulkarni RN.  2009.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150(7):2994-6.
Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R.  2009.  The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. J Biol Chem. 284(2):759-65. Abstract
Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM.  2009.  Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. Abstract
Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S.  2009.  Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse. Diabetologia. Abstract
Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC.  2009.  Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol. Abstract
Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, DeFronzo RA.  2009.  Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia. Abstract
Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I.  2009.  Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 58(1):174-84. Abstract
Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB.  2009.  Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. Embo J. 28(4):417-28. Abstract
Assmann A, Hinault C, Kulkarni RN.  2009.  Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes. 10(1):14-32.
Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A.  2009.  Mutations at the BLK locus linked to maturity onset diabetes of the young and {beta}-cell dysfunction. Proc Natl Acad Sci U S A. Abstract
Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A.  2009.  p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 23(8):1281-90. Abstract