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Recent Publications of Members of the Boston Ithaca Islet Club


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2010
Gray JP, Heart E.  2010.  Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion. Toxicol Mech Methods. 20:167-174. Abstract
2009
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ.  2009.  Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 296(6):E1354-62. Abstract
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJS.  2009.  Role for malic enzyme, pyruvate carboxylation and mitochondrial malate import in the glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. Epub. Abstract
Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.  2009.  Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells. PLoS One. 4(7):e6221. Abstract
2008
Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD.  2008.  Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol. 231(3):384-92. Abstract
Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD.  2008.  UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol. 232(1):14-24. Abstract
Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.  2008.  Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 44(6):1169-79. Abstract
Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD.  2008.  Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis. 29(1):219-25. Abstract
2007
Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, Laskin JD.  2007.  Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 282(11):7939-49. Abstract
2006
Gray JP, Davis J. W. 2, Gopinathan L, Leas TL, Nugent CA, Vanden Heuvel JP.  2006.  The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. Toxicol Sci. 89(2):535-46. Abstract
2005
Gray JP, Burns KA, Leas TL, Perdew GH, Vanden Heuvel JP.  2005.  Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry. 44(30):10313-21. Abstract
2003
Tien ES, Gray JP, Peters JM, Vanden Heuvel JP.  2003.  Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes. Cancer Res. 63(18):5767-80. Abstract
Gray JP, Leas TL, Obert E, Brown D, Clark GC, Vanden Heuvel JP.  2003.  Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake Erie. Aquat Toxicol. 64(3):343-58. Abstract