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Recent Publications of Members of the Boston Ithaca Islet Club


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2009
Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME.  2009.  ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol. Abstract
Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.  2009.  The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets. Obesity (Silver Spring). Abstract
Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS.  2009.  Mitochondrial Networking Protects Beta Cells from Nutrient Induced Apoptosis. Diabetes. Abstract
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.  2009.  Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 150(7):3040-8. Abstract
Wang T, Si Y, Shirihai OS, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE.  2009.  Respiration in Adipocytes is Inhibited by Reactive Oxygen Species. Obesity. Epub ahead Abstract
2008
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.  2008.  Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J. 27(2):433-46. Abstract
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.  2008.  Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J. 27(2):433-46. Abstract
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.  2008.  Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 14(2):144-53. Abstract
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.  2008.  Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 14(2):144-53. Abstract
2007
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.  2007.  beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 56(10):2569-78. Abstract
Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W.  2007.  Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism. 56(7):985-91. Abstract
Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM.  2007.  New scanning electron microscopic method for determination of adipocyte size in humans and mice. Obesity (Silver Spring). 15(7):1657-65. Abstract
Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S.  2007.  Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 56(7):1783-91. Abstract
Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D.  2007.  The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Biochemistry. 46(50):14461-7. Abstract
Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM.  2007.  Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology. 133(6):1796-805. Abstract
Deeney JT, Branstrom R, Corkey BE, Larsson O, Berggren PO.  2007.  3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1). FEBS Lett. 581(21):4080-4. Abstract
Branstrom R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO.  2007.  Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif. Diabetologia. 50(8):1670-7. Abstract
Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.  2007.  Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 403(1):197-205. Abstract
Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.  2007.  Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. Am J Physiol Endocrinol Metab. 292(4):E1041-51. Abstract
2006
Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W.  2006.  Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 41(3):267-71. Abstract
Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM.  2006.  Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification. Obesity (Silver Spring). 14(7):1124-31. Abstract
Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE.  2006.  Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 290(1):E143-E148. Abstract
2005
Zang Y, Wang T, Xie W, Wang-Fischer YL, Getty L, Han J, Corkey BE, Guo W.  2005.  Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res. 13(9):1530-9. Abstract
Getty-Kaushik L, Richard AM, Corkey BE.  2005.  Free fatty acid regulation of glucose-dependent intrinsic oscillatory lipolysis in perifused isolated rat adipocytes. Diabetes. 54(3):629-37. Abstract
Getty-Kaushik L, Richard AM, Corkey BE.  2005.  Glucose-dependent insulin modulation of oscillatory lipolysis in perifused rat adipocytes. Obes Res. 13(12):2058-65. Abstract