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Recent Publications from BIIC Members

  • Noradrenaline inhibits exocytosis via G{beta}{gamma} and refilling of the readily releasable granule pool via G{alpha}i-1/2.
  • Hormonal inhibition of endocytosis: Novel roles for noradrenaline and Gz.
  • Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.
  • The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell.
  • Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release.
  • Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism.
  • Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets.
  • Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.
  • Anaplerotic input is sufficient to induce time-dependent potentiation of insulin release in rat pancreatic islets.
  • Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.
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You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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Filters: Author is Petersen, K. F.  [Clear All Filters]
2008
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.  2008.  Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A. 105(50):19926-31. Abstract
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2007
Buhl ES, Neschen S, Yonemitsu S, Rossbacher J, Zhang D, Morino K, Flyvbjerg A, Perret P, Samuel V, Kim J, Cline GW, Petersen KF.  2007.  Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Am J Physiol Endocrinol Metab. 293(5):E1451-8. Abstract
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Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI.  2007.  The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 104(31):12587-94. Abstract
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