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Recent Publications of Members of the Boston Ithaca Islet Club


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2008
Leahy JL.  2008.  Mary, Mary, quite contrary, how do your beta-cells fail? Diabetes. 57(10):2563-4.
Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.  2008.  In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. J Biol Chem. 283(47):32462-70. Abstract
Lankisch MR, Ferlinz KC, Leahy JL, Scherbaum WA.  2008.  Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single-dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs. Diabetes Obes Metab. 10(12):1178-85. Abstract
Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.  2008.  Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion. Am J Physiol Endocrinol Metab. 294(4):E679-87. Abstract
2007
Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.  2007.  Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes. 56(1):88-95. Abstract
2006
Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.  2006.  Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling. Diabetologia. 49(9):2120-30. Abstract
Leahy JL.  2006.  Insulin management of diabetic patients on general medical and surgical floors. Endocr Pract. 12 Suppl 3:86-90. Abstract
Leahy JL.  2006.  Basal-prandial insulin therapy: Scientific concept review and application. Am J Med Sci. 332(1):24-31. Abstract
Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, LaRock K, Everill B, Leahy JL, Jetton TL.  2006.  Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes. 55(12):3289-98. Abstract
2005
Leahy JL.  2005.  Pathogenesis of type 2 diabetes mellitus. Arch Med Res. 36(3):197-209. Abstract
Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.  2005.  Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase. Diabetes. 54(8):2294-304. Abstract
2004
Liu YQ, Moibi JA, Leahy JL.  2004.  Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle. J Biol Chem. 279(9):7470-5. Abstract