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Recent Publications of Members of the Boston Ithaca Islet Club


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2009
Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.  2009.  Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 58(3):682-92. Abstract
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.  2009.  Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 29(11):3219-28. Abstract
Kulkarni RN.  2009.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150(7):2994-6.
Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I.  2009.  Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 58(1):174-84. Abstract
Assmann A, Hinault C, Kulkarni RN.  2009.  Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes. 10(1):14-32.
Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A.  2009.  Mutations at the BLK locus linked to maturity onset diabetes of the young and {beta}-cell dysfunction. Proc Natl Acad Sci U S A. Abstract
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.  2009.  Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 9(4):350-61. Abstract
2008
DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM.  2008.  Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 57(9):2296-303. Abstract
Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD.  2008.  Retraction. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 22(9):2203.
Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN.  2008.  Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes Obes Metab. 10 Suppl 4:136-46. Abstract
Kulkarni RN, Baskaran K.  2008.  Inheritance of pollen-less anthers and "thrum" and "pin" flowers in periwinkle. J Hered. 99(4):426-31. Abstract
Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.  2008.  Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic {beta}-cell growth. Diabetes. Abstract
Welters HJ, Kulkarni RN.  2008.  Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab. 19(10):349-55. Abstract
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR.  2008.  New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 454(7207):1000-4. Abstract
Petyuk VA, Qian WJ, Hinault C, Gritsenko MA, Singhal M, Monroe ME, Camp D. G. 2, Kulkarni RN, Smith RD.  2008.  Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res. 7(8):3114-26. Abstract
2007
Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.  2007.  Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 27(17):6026-37. Abstract
Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.  2007.  Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 117(10):2860-8. Abstract
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.  2007.  Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 117(11):3463-74. Abstract
Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.  2007.  Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 104(21):8977-82. Abstract
Pai BS, Varma RG, Kulkarni RN, Nirmala S, Manjunath LC, Rakshith S.  2007.  Microsurgical anatomy of the posterior circulation. Neurol India. 55(1):31-41. Abstract
Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN.  2007.  Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 56(2):311-9. Abstract
Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE.  2007.  A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab. 3(12):835-40. Abstract
Kulkarni RN, Kahn CR.  2007.  Ephs and ephrins keep pancreatic Beta cells connected. Cell. 129(2):241-3. Abstract
2006
Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD.  2006.  Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 20(11):2671-81. Abstract
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.  2006.  Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 26(22):8217-27. Abstract