Recent Publications from BIIC Members

Noradrenaline inhibits exocytosis via G{beta}{gamma} and refilling of the readily releasable granule pool via G{alpha}i-1/2.
Hormonal inhibition of endocytosis: Novel roles for noradrenaline and Gz.
Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.
The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell.
Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release.
Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism.
Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets.
Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.
Anaplerotic input is sufficient to induce time-dependent potentiation of insulin release in rat pancreatic islets.
Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.

You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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2008

Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG. 2008. Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol. 586(5):1307-19. Abstract

2007

Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. 2007. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 27(17):6026-37. Abstract

Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. 2007. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 117(11):3463-74. Abstract

2006

Prentki M, Nolan CJ. 2006. Islet beta cell failure in type 2 diabetes. J Clin Invest. 116(7):1802-12. Abstract