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Recent Publications of Members of the Boston Ithaca Islet Club


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2009
Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.  2009.  Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 58(3):682-92. Abstract
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.  2009.  Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 29(11):3219-28. Abstract
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ.  2009.  Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 296(6):E1354-62. Abstract
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.  2009.  Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 150(7):3040-8. Abstract
Kulkarni RN.  2009.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150(7):2994-6.
Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.  2009.  Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J Biol Chem. 284(16):10728-36. Abstract
Weir GC, Koulamnda M.  2009.  Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 diabetes. Curr Diab Rep. 9(2):100-2.
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.  2009.  Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 9(4):350-61. Abstract
2008
Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD.  2008.  Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol. 231(3):384-92. Abstract
DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM.  2008.  Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 57(9):2296-303. Abstract
Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.  2008.  The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. 57(9):2432-7. Abstract
Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HF.  2008.  Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem. 283(43):29285-91. Abstract
Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H. J, Flier JS, Strom TB.  2008.  Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 105(42):16242-7. Abstract
Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD.  2008.  UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol. 232(1):14-24. Abstract
Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC.  2008.  Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev. 24(7):585-90. Abstract
Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS.  2008.  UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 283(45):30461-70. Abstract
Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI.  2008.  N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell. 135(5):813-24. Abstract
Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.  2008.  In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. J Biol Chem. 283(47):32462-70. Abstract
Liu Z, Habener JF.  2008.  Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem. 283(13):8723-35. Abstract
Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.  2008.  Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 44(6):1169-79. Abstract
Tonomura N, Shimizu A, Wang S, Yamada K, Tchipashvili V, Weir GC, Yang YG.  2008.  Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation. 15(2):129-35. Abstract
Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A.  2008.  Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 36(Pt 3):353-6. Abstract
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.  2008.  Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J. 27(2):433-46. Abstract
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.  2008.  Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J. 27(2):433-46. Abstract
Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD.  2008.  Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis. 29(1):219-25. Abstract