Recent Publications from Members of the BIIC

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The list of publications was last updated August 26th, 2009. If you would like to add another page, email Joshua Gray with an Endnote-formatted file containing the references you would like to add. Alternatively, you may request permission to add references and, once verified as a BIIC member, you will be able to submit them yourself.

You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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2009
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.  2009.  Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 29(11):3219-28. Abstract
Kulkarni RN.  2009.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150(7):2994-6.
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.  2009.  Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 9(4):350-61. Abstract
2008
Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.  2008.  The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. 57(9):2432-7. Abstract
Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HF.  2008.  Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem. 283(43):29285-91. Abstract
Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS.  2008.  UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 283(45):30461-70. Abstract
Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A.  2008.  Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 314(2):443-56. Abstract
Poitout V.  2008.  Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube. Am J Physiol Endocrinol Metab. 294(2):E214-6.
Dallaire P, Bellmann K, Laplante M, Gelinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A.  2008.  Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes. 57(8):1999-2011. Abstract
2007
Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.  2007.  Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 27(17):6026-37. Abstract
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.  2007.  Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 104(42):16480-5. Abstract
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.  2007.  beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 56(10):2569-78. Abstract
Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.  2007.  Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 117(10):2860-8. Abstract
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.  2007.  Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 117(11):3463-74. Abstract
Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.  2007.  Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 104(21):8977-82. Abstract
Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN.  2007.  Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 56(2):311-9. Abstract
Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.  2007.  GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. 56(4):1087-94. Abstract
Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI.  2007.  n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes. 56(4):1034-41. Abstract
Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK.  2007.  Regulation of gluconeogenesis by Kruppel-like factor 15. Cell Metab. 5(4):305-12. Abstract
2006
Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD.  2006.  Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 20(11):2671-81. Abstract
Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC.  2006.  Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 55(11):2974-85. Abstract
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.  2006.  Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 26(22):8217-27. Abstract
Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA.  2006.  Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab. 290(5):E814-23. Abstract
Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY.  2006.  Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes. 55(5):1421-9. Abstract
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN.  2006.  Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet. 38(5):583-8. Abstract